After receiving her medical degree from Beijing Capital Medical University in 1983, Jingjing took a position as a research assistant professor at the Navy General Hospital in Beijing.
From 1989 to 2000 Jingjing worked in the Immunogenetics Laboratory at the Beijing Institute of Pediatrics and contributed to projects including the WHO DIAMOND Project, an IDDM molecular epidemiology in China, a study of CETP gene mutation in four Chinese populations and an HLA disease association study.
After leaving Chica, she worked for a year as a visiting scholar in the Genetic Epidemiology Unit at the National Public Health Institute in Helsinki, Finland where she studied HLA haplotypes of IDDM patients in different populations.
In late 2001 Jingjing arrived at the University of Chicago and worked for the next 15 years in the Department of Neurosurgery, where she contributed to many different projects probing immunological and neurological systems in mouse and human models.
Finally, in 2017, she joined the Esser-Kahn lab, where she assists with immunoengineering studies in mice.
M.D. Beijing Capital Medical University; Beijing P.R. China; 1983
“The only person you can rely on is yourself.”
– Danny Rubin
Jonas Edward Salk
If you could be a piece of lab equipment, what would you be?
Immunology, molecular biology, animal experiments
Nanovaccine that activates the NLRP3 inflammasome enhances tumor specific activation of anti-cancer immunity. Manna S, Maiti S, Shen J, Weiss A, Mulder E, Du W, Esser-Kahn AP. Biomaterials. 2023 May 1;296:122062. https://doi.org/10.1016/j.biomaterials.2023.122062
Temporal control of trained immunity via encapsulated release of β-glucan improves therapeutic applications, Ajit, J.; Cassaidy, B.; Tang, S.; Solanik, A.; Chen, Q.; Shen, J.; Esser-Kahn, A.P. Advanced Healthcare Materials, 2022;11(18):2200819. https://doi.org/10.1002/adhm.202200819
Improving the Adjuvanticity of Small Molecule Immune Potentiators Using Covalently Linked NF-ΚB Modulators. Kimani, F. W.; Manna, S.; Moser, B.; Shen, J.; Nihesh, N.; Esser-Kahn, A. P. ACS Med. Chem. Lett. 2021, 12 (9), 1441–1448. https://doi.org/10.1021/acsmedchemlett.1c00267.
A Synthetic Pathogen Mimetic Molecule Induces a Highly Amplified Synergistic Immune Response via Activation of Multiple Signaling Pathways. Nihesh, N.; Manna, S.; Studnitzer, B.; Shen, J.; P. Esser-Kahn, A. Chemical Science 2021. https://doi.org/10.1039/D1SC00964H.
Saikat Manna, Sampa Maiti, Jingjing Shen, Wenjun Du, Aaron P. Esser-Kahn. ACS Cent. Sci. 2020, 6, 11, 2071–2078. Oct 27, 2020. doi: 10.1021/acscentsci.0c01001
Sampa Maiti, Saikat Manna, Jingjing Shen, Aaron P. Esser-Kahn, and Wenjun Du. Mitigation of Hydrophobicity-Induced Immunotoxicity by Sugar Poly(orthoesters). Journal of the American Chemical Society. 2019.
Saikat Manna, William J. Howitz, Nathan J. Oldenhuis, Alexander C. Eldredge, Jingjing Shen, Fnu Naorem Nihesh, Melissa B. Lodoen, Zhibin Guan , and Aaron P. Esser-Kahn. Immunomodulation of the NLRP3 Inflammasome through Structure-Based Activator Design and Functional. ACS Central Science. 2018. Vol. 4 (8), Pg. 982-995.
Hussein A. Zeineddine, MD, Romuald Girard, PhD, Ying Cao, MS, Nicholas Hobson, MS, Maged D. Fam, MD, Agnieszka Stadnik, MS, Huan Tan, PhD, Jingjing Shen, MD, Kiranj Chaudagar, PhD, Robert Shenkar, PhD, Richard E. Thompson, PhD, Nichol McBee, MPH, Daniel Hanley, MD, Timothy Carroll, PhD, Gregory A. Christoforidis, MD and Issam A. Awad, MD. Quantitative susceptibility mapping as a monitoring biomarker in cerebral cavernous malformations wi. Journal of Magnetic Resonance Imaging. 2017.
Brenda Auffinger, Sandi Lam, Jingjing Shen, Ben Z. Roitberg. Measuring Surgical Outcomes in Subaxial Degenerative Cervical Spine Disease Patients: Minimum Clinic. Neurosurgery. 2014. Vol. 74, Pg. 206-214.
Brenda Auffinger, Sandi Lam. Jennifer Kraninger, Jingjing Shen, Ben Z. Roitberg. The Impact of Obesity on Surgeon Ratings and Patient-Reported Outcome Measures After Degenerative Ce. World Neurosurgery. 2013. Vol. 82, Pg. 345-352.
Brenda Auffinger, Sandi Lam, Jingjing Shen, Bart Thaci, Ben Z. Roitberg. Usefulness of minimum clinically important difference for assessing patients with subaxial degenerat. Acta Neurochirurgica. 2013. Vol. 155, Pg. 2345–2355.
Ben Z. Roitberg, Bart Thaci, Brenda Auffinger, Laura Kaplan, Jingjing Shen, Frederick D. Brown, Sandi Lam. Comparison between patient and surgeon perception of degenerative spine disease outcomes—a prospecti. Acta Neurochirurgica. 2013. Vol. 155, Pg. 757-764.
Jane H Wang, Xin Zheng, Xiaogang Ke, M Tevfik Dorak, Jingjing Shen, Basmattee Boodram, Maurice O'Gorman, Kenneth Beaman, Scott J Cotler, Ronald Hershow and Lijun Rong. Ethnic and geographical differences in HLA associations with the outcome of hepatitis C virus infect. Virology Journal. 2009. Vol. 6.
Shen Jingjing, Yang Ze, Tang Lei, Sun Yiping.. The role of HLA-DRB1*07 and Cw*0602 in development of psoriasis in Chinese patients.. Journal of Clinical Dermatology. 2001. Vol. 30, Pg. 103-116.