Publications

Weiss, A. M., Lopez, M. A., Rosenberger, M. G., Kim, J. Y., Shen, J., Chen, Q., … Esser-Kahn, A. P. (2024). Identification of CDK4/6 Inhibitors as Small Molecule NLRP3 Inflammasome Activators that Facilitate IL-1β Secretion and T Cell Adjuvanticity. Journal of Medicinal Chemistry, 67(17), 14974–14985. https://doi.org/10.1021/acs.jmedchem.4c00516

Knight, H. R., Ketter, E., Ung, T., Weiss, A., Jainu Ajit, Chen, Q., … Esser-Kahn, A. (2024). High-throughput screen identifies non inflammatory small molecule inducers of trained immunity. Proceedings of the National Academy of Sciences, 121(29). https://doi.org/10.1073/pnas.2400413121

Mulder, E. J., Moser, B., Delgado, J., Steinhardt, R., & Esser-Kahn, A. P. (2024b). Protocol for localized macrophage stimulation with small-molecule TLR agonist via fluidic force microscopy. STAR Protocols, 5(1), 102873. https://doi.org/10.1016/j.xpro.2024.102873

Cassaidy, B. J., Moser, B. A., Solanki, A., Chen, Q., Shen, J., Gotsis, K., … Esser, A. P. (2024). Immune Potentiation of PLGA Controlled-Release Vaccines for Improved Immunological Outcomes. ACS Omega, 9(10). https://doi.org/10.1021/acsomega.3c06552

Cook, A. L., Dearborn, M. A., Anderberg, T. M., Vaidya, K., Jureller, J. E., Esser-Kahn, A. P., & Squires, A. H. (2024). Polymer Patterning by Laser-Induced Multipoint Initiation of Frontal Polymerization. ACS Applied Materials & Interfaces, 16(14), 17973–17980. https://doi.org/10.1021/acsami.4c00216

Anderberg, T., Cook, A., Domurat-Sousa, K., Ejaz, A., Lin, K., Jureller, J. E., … Squires, A. (2024). An anti-Brownian magnetic feedback trap for bio-orthogonal manipulation of nanoparticles. Biophysical Journal, 123(3), 151a151a. https://doi.org/10.1016/j.bpj.2023.11.1031

Mulder, E. J., Moser, B., Delgado, J., Steinhardt, R. C., & Esser-Kahn, A. P. (2024). Evidence of collective influence in innate sensing using fluidic force microscopy. Frontiers in Immunology, 15. https://doi.org/10.3389/fimmu.2024.1340384

Jia, S., Kim, J., Esser-Kahn, A. P., & Deak, P. (2024). High-throughput screening identification of novel immunomodulatory combinations for the generation of tolerogenic dendritic cells. Frontiers in Medicine, 10. https://doi.org/10.3389/fmed.2023.1298424

Poston, T. B., Girardi, J., Kim, M., Zwarycz, P., Polson, A. G., Yount, K. S., … Darville, T. (2024). Intranasal immunization with CPAF combined with cyclic-di-AMP induces a memory CD4 T cell response and reduces bacterial burden following intravaginal infection with Chlamydia muridarum. Preprint at BioRxiv. https://doi.org/10.1101/2024.09.20.614154

Ajit, J., Chen, Q., Ung, T., Rosenberger, M., Kim, J., Solanki, A., … Esser, A. P. (2024). β-glucan induced trained immunity enhances antibody levels in a vaccination model in mice. Preprint at BioRxiv. https://doi.org/10.1101/2024.04.11.588932

Ajit, J., Knight, H. R., Chen, Q., Solanki, A., Shen, J., & Esser, A. P. (2024). Novel non-immunogenic trained immunity inducing small molecule with improved anti-tumor properties. Preprint at BioRxiv. https://doi.org/10.1101/2024.03.22.585780

Ayarza, J., Wang, J., Kim, H., Huang, P.-R., Cassaidy, B., Yan, G., … Esser-Kahn, A. P. (2023). Bioinspired mechanical mineralization of organogels. Nature Communications, 14(1). https://doi.org/10.1038/s41467-023-43733-x

Kim, H., Esser-Kahn, A. P., Rowan, S. J., & Jaeger, H. M. (2023). Stress-activated friction in sheared suspensions probed with piezoelectric nanoparticles. Proceedings of the National Academy of Sciences, 120(49). https://doi.org/10.1073/pnas.2310088120

Si, Y., Wang, Y., Tian, Q., Wang, Q., Pollard, J. M., Srivastava, P. K., … Chong, A. S. (2023). Lung cDC1 and cDC2 dendritic cells priming naive CD8+ T cells in situ prior to migration to draining lymph nodes. Cell Reports, 42(10), 113299–113299. https://doi.org/10.1016/j.celrep.2023.113299

Weiss, A. M., Lopez, M. A., Rawe, B. W., Manna, S., Chen, Q., Mulder, E. J., … Esser-Kahn, A. P. (2023). Understanding How Cationic Polymers’ Properties Inform Toxic or Immunogenic Responses via Parametric Analysis. Macromolecules, 56(18), 7286–7299. https://doi.org/10.1021/acs.macromol.3c01223

Ung, T., Rutledge, N. S., Weiss, A. M., Esser‐Kahn, A. P., & Deak, P. E. (2023). Cell-targeted vaccines: implications for adaptive immunity. Frontiers in Immunology, 14. https://doi.org/10.3389/fimmu.2023.1221008

Guo, X., Xie, M., Addhya, A., Linder, A., Zvi, U., Deshmukh, T. D., … High, A. A. (2023). Direct-bonded diamond membranes for heterogeneous quantum and electronic technologies. Preprint at arXiv. https://doi.org/10.48550/arxiv.2306.04408

Rosenberger, M. G., Kim, J., & Esser-Kahn, A. (2023). Immunomodulators identified via high-throughput screening enhance control of vaccine adjuvanticity. The Journal of Immunology, 210(1_Supplement), 145.23–145.23. https://doi.org/10.4049/jimmunol.210.supp.145.23

Esser-Kahn, A. P. (2023). Innate Immune Memory for Improved Vaccine Response. The Journal of Immunology, 210(1_Supplement), 223.10–223.10. https://doi.org/10.4049/jimmunol.210.supp.223.10

Esser-Kahn, A. P., Rosenberger, M. G., & Kim, J. (2023). Modulating Innate Immune Responses for Improved Vaccine Tolerability and Durability. The Journal of Immunology, 210(1_Supplement), 223.09–223.09. https://doi.org/10.4049/jimmunol.210.supp.223.09

Esser-Kahn, A. P., & Ung, T. W. M. (2023). Identifying and targeting a subpopulation of dendritic cells with enhanced activation of adaptive responses - identifying first responders. The Journal of Immunology, 210(1_Supplement), 72.40–72.40. https://doi.org/10.4049/jimmunol.210.supp.72.40

Weiss, A. M., Rosenberger, M. G., Kim, J. Y., Lopez, M. A., Rowan, S. J., & Esser-Kahn, A. P. (2023). High Throughput Screening Identifies CDK Inhibitors as Inflammasome-Activating Vaccine Adjuvants. The Journal of Immunology, 210(1_Supplement), 145.24–145.24. https://doi.org/10.4049/jimmunol.210.supp.145.24

Tang, Y., Kim, J., IP, C. K., Azadeh Bahmani, Chen, Q., Rosenberger, M. G., … Ferguson, A. L. (2023). Data-driven discovery of innate immunomodulators via machine learning-guided high throughput screening. Chemical Science, 14(44). https://doi.org/10.1039/d3sc03613h

Kim, J. Y., Rosenberger, M. G., Rutledge, N. S., & Esser-Kahn, A. P. (2023). Next-Generation Adjuvants: Applying Engineering Methods to Create and Evaluate Novel Immunological Responses. Pharmaceutics, 15(6), 1687.

https://www.mdpi.com/1999-4923/15/6/1687

Manna S, Maiti S, Shen J, Weiss A, Mulder E, Du W, Esser-Kahn AP. Nanovaccine that activates the NLRP3 inflammasome enhances tumor specific activation of anti-cancer immunity. Biomaterials. 2023 May 1;296:122062. https://doi.org/10.1016/j.biomaterials.2023.122062

Kim, J. Y., Rosenberger, M. G., Chen, S., Ip, C. K., Bahmani, A., Chen, Q., ... & Esser-Kahn, A. P. (2023). Discovery of New States of Immunomodulation for Vaccine Adjuvants via High Throughput Screening: Expanding Innate Responses to PRRs. ACS Central Science, 9(3), 427-439. https://pubs.acs.org/doi/full/10.1021/acscentsci.2c01351

Uri Zvi, Adam Weiss, Denis Candido, Aidan Jones, Michael Flatté, Peter Maurer, Aaron Esser-Kahn, Iryna Golovina, Lingjie Chen Engineering Spin Coherence in Core-Shell Diamond Nanocrystals Bulletin of the American Physical Society 2023
https://doi.org/10.48550/arXiv.2305.03075

Adam M. Weiss, Aaron P. Esser-Kahn, Size matters in non-canonical inflammasome activation and cell-mediated immunity  Cell Reports Medicine 2023

https://doi.org/10.1016/j.xcrm.2022.100904

Chattopadhyay, Ishanu, Kevin Wu, Jin Li, and Aaron Esser-Kahn. Emergenet: Fast Scalable Pandemic Risk Assessment of Influenza A Strains Circulating In Non-human Hosts. 2022 https://doi.org/10.21203/rs.3.rs-2336091/v1

Chao-Wei Huang, Jun Wang, Zhao Wang, Jorge Ayarza, and Aaron P. Esser-Kahn

Enhancing the Piezoelectric Voltage Output in a Gel Composite through the Tuning of the Matrix Dielectric Constant ACS Applied Engineering Materials 2022 https://doi.org/10.1021/acsaenm.2c00032

Deak, P. E., Studnitzer, B., Ung, T. , Steinhardt, R., Swartz, M., & Esser-Kahn, A. Isolating and Targeting a Highly Active, Stochastic Dendritic Cell
Subpopulation for Improved Immune Responses. Cell Reports 2022 Nov 1;41(5):111563.
https://doi.org/10.1016/j.celrep.2022.111563

A.M. Weiss, S. Hossainy, S.J. Rowan, J.A. Hubbell, A.P. Esser-Kahn. Immunostimulatory Polymers as Adjuvants, Immunotherapies, and Delivery Systems. Macromolecules 2022 55, 16, 6913–6937. https://doi.org/10.1021/acs.macromol.2c00854

Ajit, J.; Cassaidy, B.; Tang, S.; Solanik, A.; Chen, Q.; Shen, J.; Esser-Kahn, A.P. Temporal control of trained immunity via encapsulated release of β-glucan improves therapeutic applications, Advanced Healthcare Materials, https://doi.org/10.1002/adhm.202200819

Deak, P.; Knight, R;Esser-Kahn, A.P. Robust Tolerogenic Dendritic Cells via Push/PullPairing of Toll-like-Receptor Agonists and Immunomodulators Reduces EAE, Biomaterials,2022. https://doi.org/10.1016/j.biomaterials.2022.121571

Deak, P. Studnizter, B, Ung, T, Steinhardt, R. Swartz, M and Esser-Kahn, A.P. Isolating and Targeting a Highly Active, Stochastic Dendritic Cell Subpopulation for Improved Immune Responses. Cell Reports, BioRxiv 2022 http://dx.doi.org/10.2139/ssrn.4093302

Kim, S.M., Studnitzer, B. Esser-Kahn, A. P. Heat Shock Protein (HSP) 90's Mechanistic Role in Contact Hypersensitivity, Journal of Immunology. Accepted, 2022,  https://doi.org/10.4049/jimmunol.2101023

Hernandez-Davies, J.; Dollinger, E.; Pone, E.; Felgner, J.; Strohmeier, S.; Jan, S.; Albin, T.; Jain, A.; Nakajima, R.; Jasinskas, A. and Esser-Kahn, A.P.  Magnitude and Breadth of Antibody Cross-Reactivity Induced by Recombinant Influenza Hemagglutinin Trimer Vaccine Is Enhanced by Combination Adjuvants. 2021. Scientific Reports.  https://doi.org/10.1038/s41598-022-12727-y

Gao, Y.; Dearborn, M. A.; Vyas, S.; Kumar, A.; Hemmer, J.; Wang, Z.; Wu, Q.; Alshangiti, O.; Moore, J. S.; Esser-Kahn, A. P.; Geubelle, P. H. Manipulating Frontal Polymerization and Instabilities with Phase-Changing Microparticles. J. Phys. Chem. B2021, 125(27), 7537–7545. https://doi.org/10.1021/acs.jpcb.1c03899.

Kimani, F. W.; Manna, S.; Moser, B.; Shen, J.; Nihesh, N.; Esser-Kahn, A. P. Improving the Adjuvanticity of Small Molecule Immune Potentiators Using Covalently Linked NF-ΚB Modulators. ACS Med. Chem. Lett. 2021, 12 (9), 1441–1448. https://doi.org/10.1021/acsmedchemlett.1c00267.

Gao, Y.; Dearborn, M. A.; Hemmer, J.; Wang, Z.; Esser-Kahn, A. P.; Geubelle, P. H. Controllable Frontal Polymerization and Spontaneous Patterning Enabled by Phase-Changing Particles. Small2021, 17(42), 2102217.https://doi.org/10.1002/smll.202102217

Ayarza, J.; Wang, Z.; Wang, J.; Esser-Kahn, A. P. Mechanically Promoted Synthesis of Polymer Organogels via Disulfide Bond Cross-Linking. ACS Macro Lett.2021, 10(7), 799–804. https://doi.org/10.1021/acsmacrolett.1c00337.

Weiss, A. M.; Ajit, J.; Albin, T. J.; Kapoor, N.; Maroju, S.; Berges, A.; Pill, L.; Fairman, J.; Esser-Kahn, A. P. Site-Specific Antigen-Adjuvant Conjugation Using Cell-Free Protein Synthesis Enhances Antigen Presentation and CD8 + T-Cell Response. Scientific Reports 2021, 11(1), 6267. https://doi.org/10.1038/s41598-021-85709-1.

Wang, Z.; Wang, J.; Ayarza, J.; Steeves, T.; Hu, Z.; Manna, S.; Esser‐Kahn, A. P. Bio-Inspired Mechanically Adaptive Materials through Vibration-Induced Crosslinking. Nature Materials 2021, 1–6. https://doi.org/10.1038/s41563-021-00932-5.

Fratzke, A. P.; Jan, S.; Felgner,J.; Liang, L.; Nakajima, R.; Jasinskas, A.; Manna, S.; Nihesh, F. N.; Maiti, S.; Albin, T. J.; Esser-Kahn, A. P.; Davies, D. H.; Samuel, J. E.; Felgner, P. L.; Gregory, A. E. Subunit Vaccines Using TLR Triagonist Combination Adjuvants Provide Protection Against Coxiella Burnetii While Minimizing Reactogenic Responses. Front. Immunol.2021, 12. https://doi.org/10.3389/fimmu.2021.653092.

Weiss, A. M.; Macke, N.; Zhang, Y.; Calvino, C.;Esser-Kahn, A. P.; Rowan, S. J. In Vitro and in Vivo Analyses of the Effects of Source, Length, and Charge on the Cytotoxicity and Immunocompatibility of Cellulose Nanocrystals. ACS Biomater. Sci. Eng.2021, 7(4), 1450–1461. https://doi.org/10.1021/acsbiomaterials.0c01618.

Kimani, F. W.; Ajit, J.; Galluppi, A.; Manna, S.; Howitz, W. J.; Tang, S.; Esser-Kahn, A. P. Receptor–Ligand Kinetics Influence the Mechanism of Action of Covalently Linked TLR Ligands. ACSChem. Biol.2021, 16(2), 380–388. https://doi.org/10.1021/acschembio.0c00924.

Nihesh, N.; Manna, S.; Studnitzer,B.; Shen, J.; P.Esser-Kahn, A. A Synthetic Pathogen Mimetic Molecule Induces a Highly Amplified Synergistic Immune Response via Activation of Multiple Signaling Pathways. Chemical Science 2021.  https://doi.org/10.1039/D1SC00964H.

McCormickSteeves, T.; Esser-Kahn, A. P. Demonstration of the Photothermal Catalysis of the Sabatier Reaction Using Nickel Nanoparticles and Solar Spectrum Light. RSC Advances2021, 11(14), 8394–8397. https://doi.org/10.1039/D0RA09939B.

Manna, S.; Maiti, S.; Shen, J.; Du, W.; Esser-Kahn, A. P. Pathogen-like Nanoassemblies of Covalently Linked TLR Agonists Enhance CD8 and NK Cell-Mediated Antitumor Immunity. ACS Cent. Sci.2020, 6(11), 2071–2078. https://doi.org/10.1021/acscentsci.0c01001.

Maiti, S.; Manna, S.; Banahene, N.; Pham, L.; Liang, Z.; Wang, J.; Xu, Y.; Bettinger, R.; Zientko, J.; Esser‐Kahn, A. P.; Du, W. From Glucose to Polymers: A Continuous Chemoenzymatic Process. Angewandte Chemie2020, 132(43), 19105–19109. https://doi.org/10.1002/ange.202006468.

Moser, B. A.; Steinhardt, R. C.; Escalante-Buendia, Y.; Boltz, D. A.; Barker, K. M.; Cassaidy, B. J.; Rosenberger, M. G.; Yoo, S.; McGonnigal, B. G.; Esser-Kahn, A. P. Increased Vaccine Tolerability and Protection via NF-ΚB Modulation. Science Advances2020, 6(37), eaaz8700. https://doi.org/10.1126/sciadv.aaz8700.

Ayarza, J.; Wang, Z.; Wang, J.; Huang, C.-W.; Esser-Kahn, A. P. 100th Anniversary of Macromolecular Science Viewpoint: Piezoelectrically Mediated Mechanochemical Reactions for Adaptive Materials. ACS Macro Lett.2020, 9(9), 1237–1248. https://doi.org/10.1021/acsmacrolett.0c00477.

Deak, P.; Kimani, F.; Cassaidy, B.; Esser-Kahn, A. Determining Whether Agonist Density or Agonist Number Is More Important for Immune Activation via Micoparticle Based Assay. Front. Immunol.2020, 11. https://doi.org/10.3389/fimmu.2020.00642.

Moser, B. A.; Escalante-Buendia, Y.; Steinhardt, R. C.; Rosenberger, M. G.; Cassaidy, B. J.; Naorem, N.; Chon, A. C.; Nguyen, M. H.; Tran, N. T.; Esser-Kahn, A. P. Small Molecule NF-ΚB Inhibitors as Immune Potentiators for Enhancement of Vaccine Adjuvants. Front Immunol 2020, 11. https://doi.org/10.3389/fimmu.2020.511513.

Gilkes, A. P.; Albin, T. J.; Manna, S.; Supnet, M.; Ruiz, S.; Tom, J.; Badten, A. J.; Jain, A.; Nakajima, R.; Felgner, J.; Davies, D. H.; Stetkevich, S. A.; Zlotnik, A.; Pearlman, E.; Nalca, A.; Felgner, P. L.; Esser-Kahn, A. P.; Burkhardt, A. M. Tuning Subunit Vaccines with Novel TLR Triagonist Adjuvants to Generate Protective Immune Responses against Coxiella Burnetii. The Journal of Immunology 2019. https://doi.org/10.4049/jimmunol.1900991.

Albin, T. J.; Tom, J. K.; Manna, S.; Gilkes, A.P.; Stetkevich, S. A.; Katz, B. B.; Supnet, M.; Felgner, J.; Jain, A.; Nakajima, R.; Jasinskas, A.; Zlotnik, A.; Pearlman, E.; Davies, D. H.; Felgner, P. L.; Burkhardt, A. M.; Esser-Kahn, A. P. Linked Toll-Like Receptor Triagonists Stimulate Distinct, Combination-Dependent Innate Immune Responses. ACS Cent. Sci.2019, 5(7), 1137–1145. https://doi.org/10.1021/acscentsci.8b00823.

Wang, Z.; Ayarza, J.; Esser‐Kahn, A. P. Mechanically Initiated Bulk-Scale Free-Radical Polymerization. Angewandte Chemie International Edition2019, 58(35), 12023–12026. https://doi.org/10.1002/anie.201903956.

Kimani, F.; Kim, S.-M.; Steinhardt, R.; Esser-Kahn, A. P. Correlating the Structure and Reactivity of a Contact Allergen, DNCB, and Its Analogs to Sensitization Potential. Bioorganic & Medicinal Chemistry2019, 27(13), 2985–2990. https://doi.org/10.1016/j.bmc.2019.05.017.

Tom, J. K.; Albin, T. J.; Manna, S.; Moser, B. A.; Steinhardt, R. C.; Esser-Kahn, A. P. Applications of Immunomodulatory Immune Synergies to Adjuvant Discovery and Vaccine Development. Trends in Biotechnology2019, 37(4), 373–388. https://doi.org/10.1016/j.tibtech.2018.10.004.

Maiti, S.; Manna, S.; Shen, J.; Esser-Kahn, A. P.; Du, W. Mitigation of Hydrophobicity-Induced Immunotoxicity by Sugar Poly(Orthoesters). J. Am. Chem. Soc.2019, 141(11), 4510–4514. https://doi.org/10.1021/jacs.8b12205.

Brubaker, K. S.; Kleiman, M.; Hernandez, L.; Bhattacharjee, A.; Esser-Kahn, A. P. Structural Remodeling of Polymeric Material via Diffusion Controlled Polymerization and Chain Scission. Chem. Mater.2018, 30(22), 8126–8133. https://doi.org/10.1021/acs.chemmater.8b02293.

Mohapatra, H.; Ayarza, J.; Sanders, E. C.; Scheuermann, A. M.;Griffin, P. J.; Esser‐Kahn, A. P. Ultrasound Promoted Step-Growth Polymerization and Polymer Crosslinking Via Copper Catalyzed Azide–Alkyne “Click” Reaction. Angewandte Chemie2018, 130(35), 11378–11382 https://doi.org/10.1002/anie.201804451

Esser-Kahn, A. P. Kiss-and-Tell Way to Track Cell Contacts. Nature 2018, 553 (7689), 414.https://doi.org/10.1038/d41586-018-00488-6

Manna, S.; Howitz, W. J.; Oldenhuis, N. J.; Eldredge, A. C.; Shen, J.; Nihesh, F. N.; Lodoen, M. B.; Guan, Z.; Esser-Kahn, A. P. Immunomodulation of the NLRP3 Inflammasome through Structure-Based Activator Design and Functional Regulation via Lysosomal Rupture. ACS Cent. Sci. 2018, 4 (8), 982–995. https://doi.org/10.1021/acscentsci.8b00218

Ignacio, B. J.; Albin, T. J.; Esser-Kahn, A. P.; Verdoes, M. Toll-like Receptor Agonist Conjugation: A Chemical Perspective. Bioconjug. Chem. 2018, 29 (3), 587–603.https://doi.org/10.1021/acs.bioconjchem.7b00808

Brubaker, K.; Garewal, A.; Steinhardt, R. C.; Esser-Kahn, A. P. Bio-Inspired Counter-Current Multiplier for Enrichment of Solutes. Nature Communications 2018, 9 (1), 736. https://doi.org/10.1038/s41467-018-03052-y

Lybaert, L.; Ryu, K. A.; Nuhn, L.; De Rycke, R.; De Wever, O.;Chon, A. C.; Esser-Kahn, A. P.; De Geest, B. G. Cancer Cell Lysate Entrapment in CaCO3 Engineered with Polymeric TLR-Agonists: Immune-Modulating Microparticles in View of Personalized Antitumor Vaccination. Chemistry of Materials 2017, 29(10), 4209–4217. https://doi.org/10.1021/acs.chemmater.6b05062

Lybaert, L.; Ryu, K. A.; De Rycke, R.; Chon, A. C.; De Wever, O.; Vermaelen, K. Y.; Esser-Kahn, A.; De Geest, B. G. Polyelectrolyte-Enrobed Cancer Cells in View of Personalized Immune-Therapy. Adv Sci (Weinh)2017, 4(6), 1700050. https://doi.org/10.1002/advs.201700050

Steinhardt, R. C.; Steeves, T. M.; Wallace, B. M.; Moser, B.; Fishman, D. A.; Esser-Kahn, A. P. Photothermal Nanoparticle Initiation Enables Radical Polymerization and Yields Unique, Uniform Microfibers with Broad Spectrum Light. ACS Appl. Mater. Interfaces2017, 9(44), 39034–39039. https://doi.org/10.1021/acsami.7b12230

Steinhardt, R.; Hiew, S. C.; Mohapatra, H.; Nguyen, D.; Oh, Z.; Truong, R.;Esser-Kahn, A. Cooperative CO2 Absorption Isotherms from a Bifunctional Guanidine and Bifunctional Alcohol. ACS Cent. Sci.2017, 3(12), 1271–1275. https://doi.org/10.1021/acscentsci.7b00418

Ryu, K. A.; McGonnigal, B.; Moore, T.; Kargupta, T.; Mancini, R. J.; Esser-Kahn, A. P. Light Guided In-Vivo Activation of Innate Immune Cells with Photocaged TLR 2/6 Agonist. Scientific Reports 2017, 7 (1), 8074. https://doi.org/10.1038/s41598-017-08520-x

Moser, B. A., Steinhardt, R. C. & Esser-Kahn, A. P. Surface Coating of Nanoparticles Reduces Background Inflammatory Activity while Increasing Particle Uptake and Delivery. ACS Bio. Sci. Eng. (2016).  https://doi.org/10.1021/acsbiomaterials.6b00473

Moser, B. A.; Esser-Kahn, A. P. A Photoactivatable Innate Immune Receptor for Optogenetic Inflammation. ACS Chem. Biol. 2017, 12 (2), 347 - 350.   https://doi.org/10.1021/acschembio.6b01012

Ryu, K. A.; Slowinska, K.; Moore, T.; Esser-Kahn, A. Immune Response Modulation of Conjugated Agonists with Changing Linker Length. ACS Chem. Biol. 2016, 11 (12), 3347–3352.   https://doi.org/10.1021/acschembio.6b00895

Mohapatra, H., Kleiman, M. & Esser-Kahn, A. P. Mechanically controlled radical polymerization initiated by ultrasound. Nat Chem 9, 135–139 (2017). https://doi.org/10.1038/nchem.2633

Goetz, S. A.; Nguyen, D. T.; Esser-Kahn, A. P. Surface modification of carbon black nanoparticles enhances photothermal separation and release of CO2 Carbon 2016, 105, 126.  https://doi.org/10.1016/j.carbon.2016.03.053

Nguyen, D. T., Kleiman, M, Esser-Kahn, A. P. Solvent Effects on the Photothermal Regeneration of CO2 in Monoethanolamine Nanofluids ACS Appl. Mater. Interfaces 2015, 7 (46)   https://doi.org/10.1021/acsami.5b08151

Tom, J. K.; Dotsey, E. Y.; Wong, H. Y.; Stutts, L.; Moore, T.; Davies, D. H.; Felgner, P. L.; Esser-Kahn, A. P. Modulation of Innate Immune Responses via Covalently Linked TLR Agonists, ACS Cent. Sci. 2015, 1 (8), 439. https://doi.org/10.1021/acscentsci.5b00274

Geoffrey M. Lynn, Richard Laga, Patricia A. Darrah, Andrew S. Ishizuka, Alexandra J. Balaci, Andres E. Dulcey, Michal Pechar, Robert Pola, Michael Y. Gerner, Ayako Yamomoto, Connor R. Buechler, Kylie M. Quinn, Margery G. Smelkinson, Ondrej Vanek, Ryan Cawood, Thomas Hills, Olga Vasalatiy, Kathrin Kastenmuller, Joseph R. Francica, Lalisa Stutts, Janine K. Tom, Keun Ah Ryu, Aaron P. Esser-Kahn, Tomas Etrych, Kerry D. Fisher, Leonard W. Seymour, and Robert A. Seder. Characterizing the physicochemical properties of TLR agonist delivery that enhance vaccine immunogenicity. Nat Biotech 2015, 33 (11), 1201.  https://doi.org/10.1038/nbt.3371

Kleiman, M.; Ryu, K. A.; Esser-Kahn, A. P. Determination of Factors Influencing the Wet Etching of Polydimethylsiloxane Using Tetra-n-butylammonium Fluoride Macromol. Chem. Phys. 2016, 217 (2), 284.  https://doi.org/10.1002/macp.201500225

Lalisa Stutts, Aaron P. Esser-Kahn A Light-Controlled TLR4 Agonist and Selectable Activation of Cell Subpopulations, ChemBioChem 2015, 16 (12), 1744.  https://doi.org/10.1002/cbic.201500164

Kuo, C.-C.; Li, Y.; Nguyen, D.; Buchsbaum, S.; Innes, L.; Esser-Kahn, A. P.; Valdevit, L.; Sun, L.; Siwy, Z.; Dennin, M. Macroscopic strain controlled ion current in an elastomeric microchannel Journal of Applied Physics 2015, 117 (17), 174904.   https://doi.org/10.1063/1.4919353

Kleiman, M, Brubaker, K. Nguyen, D. T., Esser-Kahn, A. P. Bio-inspired Morphogenesis Using Microvascular Networks and Reaction-Diffusion, (2015) Chem. Mater. 2015, 27 (13), 4871. https://doi.org/10.1021/acs.chemmater.5b01947

Rock J. Mancini, Lalisa Stutts, Aaron P. Esser-Kahn. Controlling the Origins of Inflammation with a Photoactive Lipopeptide Immunopotentiator, Angew. Chem. Int. Ed. 2015, 54 (20), 5962. Selected as Hot Paper. https://doi.org/10.1002/anie.201500416

Nguyen, D. T., Kleiman, M, Esser-Kahn, A. P. Bio-inspired Microvascular Exchangers Employing Circular Packing – Synthetic Rete Mirabile, (2014) Mater. Horiz. 2014, 1 (6), 602-607.   https://doi.org/10.1039/C4MH00120F

Ryu, K. A., Stutts, L., Tom, J. K., Mancini, R. J., and Esser-Kahn, A. P. Stimulation of Innate Immune Cells by Light-Activated TLR7/8 Agonists J. Am. Chem. Soc. 2014, 136 (31), 10823. https://doi.org/10.1021/ja412314j

Nguyen, D. T., Truong, R., Lee, R., Goetz, S. A., and Esser-Kahn, A. P. Photothermal Release of CO2 from Capture Solutions Using Nanoparticles Energy & Environmental Science 7, no. 8 (2014): 2603–2607. https://doi.org/10.1039/C4EE01047G

Nguyen, D. T., Kleiman, M., Ryu, K. A., Hiew, S., Brubaker, K., Mughnetsyan, R., Truong, R., Dolan, B., Tackett, E., and Esser-Kahn, A. P. Three-Dimensional Conformal Coatings through the Entrapment of Polymer Membrane Precursors ACS Applied Materials & Interfaces 6, no. 4 2014: 2830–2835. https://doi.org/10.1021/am4053943

Mancini, R. J., Stutts, L., Ryu, K. A., Tom, J. K., and Esser-Kahn, A. P. Directing the Immune System with Chemical Compounds ACS Chemical Biology 9, no. 5 2014: 1075–1085. https://doi.org/10.1021/cb500079s

Mancini, R. J, J. K. Tom L. Stutts, Esser-Kahn, A. P. Covalently Coupled Immuno-stimulant Heterodimers. Angew. Chem. 2014, 126, 193. https://doi.org/10.1002/ange.201306551

Nguyen, D. T., Esser-Kahn, A. P. A Microvascular System for Chemical Reactions Using Surface Waste Heat Angew. Chem 2013, 52, 13731. https://doi.org/10.1002/anie.201306928

Nguyen, D. T., Leho, Y. T, Esser-Kahn, A. P. Process of Making Three-Dimensional Micro-Exchange Units using Vaporization of a Sacrificial Component J. Vis. Exp. (81), e50459, 2013.  https://doi.org/10.3791/50459

Tom, J. K.; Mancini, R. J.; Esser-Kahn, A. P. Covalent modification of cell surfaces with TLR agonists improves & directs immune stimulation Chem. Commun. (Camb.) 2013, 49, 9618.   https://doi.org/10.1039/C3CC45468A

Nguyen, D. T., Leho, Y. T. & Esser-Kahn, A. P. The Effect of Membrane Thickness on a Microvascular Gas Exchange Unit. Advanced Functional Materials 2013, 23 (1), 100. https://doi.org/10.1002/adfm.201201334

Nguyen, D. T., Leho, Y. T. & Esser-Kahn, A. P. A Three-Dimensional Microvascular Gas Exchange Unit for Carbon Dioxide Capture. Lab on a Chip 2012, 12, 1246-1250. https://doi.org/10.1039/C2LC00033D

Dong, H.; Esser-Kahn, A. P.; Thakre, P. R.; Patrick, J. F.; Sottos, N. R.; White, S. R.; Moore, J. S. Chemical Treatment of Poly(lactic acid) Fibers to Enhance the Rate of Thermal Depolymerization ACS Applied Materials & Interfaces (2011), 4, 503–509.

https://doi.org/10.1021/am2010042

Esser-Kahn, A.P.;* Odom, S.A.;* Sottos, N.R.; White, S. R.; Moore, J.S. Triggered Release from Polymer Capsules. Macromolecules (2011), 44, 5539-5553.    https://doi.org/10.1021/ma201014n

A. P. Esser-Kahn, P. R. Thakre, H. Dong, J. F. Patrick, N. R. Sottos, J. S. Moore, S. R. White Three-Dimensional Microvascular Fiber-Reinforced Composites Adv. Mat. (2011), 23, 3654–3658. https://doi.org/10.1002/adma.201100933

L. S. Witus, T. Moore, B. W. Thuronyi, A. P. Esser-Kahn, R. A. Scheck, A. T. Iavarone, and M. B. Francis. Identification of Highly Reactive Sequences For PLP-Mediated Bioconjugation Using a Combinatorial Peptide Library J. Am. Chem. Soc. (2010), 132, 16812-16817.  

https://doi.org/10.1021/ja105429n

A. P. Esser-Kahn, V. Trang, M. B. Francis, Incorporation of Anti-Freeze Proteins into Polymer Coatings Using Site-Selective Bioconjugation J. Am. Chem. Soc. (2010), 132, 13264-13269. 

https://doi.org/10.1021/ja103038p

A. P. Esser-Kahn, N. R. Sottos, S. R. White, J. S. Moore, Programmable Microcapsules from Self-Immolative Polymers J. Am. Chem. Soc (2010), 132, 10266-10268. Selected for Faculty of 1000. https://doi.org/10.1021/ja104812p

A. P. Esser-Kahn, A. T. Iavarone, M. B. Francis, Metallothionein-Crosslinked Hydrogels for the Selective Removal of Heavy Metals from Water, J. Am. Chem. Soc (2008), 130, 15820-15822. https://doi.org/10.1021/ja807095r

A. P. Esser-Kahn, M. B. Francis, Protein-Crosslinked Polymeric Materials Through Site-Selective Bioconjugation Angew. Chem., Int. Ed. (2008) 47, 375-378. Selected as Hot Paper. https://doi.org/10.1002/ange.200705564

J. M. Hooker, A. P. Esser-Kahn, M. B. Francis. Modification of Aniline Containing Proteins Using an Oxidative Coupling Strategy J. Am. Chem. Soc. (2006), 128, 15558–15559. 

https://doi.org/10.1021/ja064088d

J. M. Gilmore,† R. A. Scheck,† A. P. Esser-Kahn, N. S. Joshi, M. B. Francis, N-Terminal Protein Modification through a Biomimetic Transamination Reaction Angew. Chem., Int. Ed. (2006), 45, 5307-5311.   https://doi.org/10.1002/anie.200600368